Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes

Abstract

Despite the theoretical bases for the association of topoisomerases and supercoiling changes with transcription and replication, our knowledge of the impact of topological constraints on transcription and replication is incomplete. Although mutation of topoisomerases affects expression and stability of the rDNA region it is not clear whether the same is the… (More)
DOI: 10.1093/nar/gkr840

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