Topological analysis of the major protein in isolated intact rat liver gap junctions and gap junction-derived single membrane structures.

@article{Zimmer1987TopologicalAO,
  title={Topological analysis of the major protein in isolated intact rat liver gap junctions and gap junction-derived single membrane structures.},
  author={Danna B. Zimmer and C. R. Green and W. Howard Evans and Norton B. Gilula},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 16},
  pages={
          7751-63
        }
}
The topological organization of the major rat liver gap junction protein has been examined in intact gap junctions and gap junction-derived single membrane structures. Two methods, low pH and urea at alkaline pH, were used to "transform" or "split" double membrane gap junctions into single membrane structures. Low pH treatment "transforms" rat liver gap junctions into small single membrane vesicles which have an altered sodium dodecyl sulfate-polyacrylamide gel electrophoresis profile after… CONTINUE READING
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