Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein*

@inproceedings{Konitsiotis2015TopologicalAO,
  title={Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein*},
  author={Antonio D. Konitsiotis and Biljana Jovanovi{\'c} and Paulina Ciepla and Martin Spitaler and Thomas Lanyon-Hogg and Edward W Tate and Anthony I. Magee},
  booktitle={The Journal of biological chemistry},
  year={2015}
}
Hedgehog proteins are secreted morphogens that play critical roles in development and disease. During maturation of the proteins through the secretory pathway, they are modified by the addition of N-terminal palmitic acid and C-terminal cholesterol moieties, both of which are critical for their correct function and localization. Hedgehog acyltransferase (HHAT) is the enzyme in the endoplasmic reticulum that palmitoylates Hedgehog proteins, is a member of a small subfamily of membrane-bound O… CONTINUE READING
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