Topoisomerases and tubulin inhibitors: a promising combination for cancer treatment.

@article{Rudolf2003TopoisomerasesAT,
  title={Topoisomerases and tubulin inhibitors: a promising combination for cancer treatment.},
  author={Emil Rudolf and Miroslav {\vC}ervinka},
  journal={Current medicinal chemistry. Anti-cancer agents},
  year={2003},
  volume={3 6},
  pages={421-9}
}
Modern approaches to treatment of cancer seek to activate the internal suicide program in the malignant cells, and thereby effectively eliminate them without engaging most of other bodily systems. Many currently used cytostatics are known to induce apoptosis and efforts are being paid to develop new ones with better and more effective proapoptotic potential. Nevertheless, despite recent developments in this field, there are still numerous malignancies showing a varying degree of resistance to… CONTINUE READING