Topoisomerase poisoning activity of novel disaccharide anthracyclines.

  title={Topoisomerase poisoning activity of novel disaccharide anthracyclines.},
  author={F Guano and Phillipe Pourquier and Stella Tinelli and Monica Binaschi and Mario Bigioni and Fabio Animati and Stefano Manzini and Franco Zunino and Glenda Kohlhagen and Yves Pommier and Giovanni Capranico},
  journal={Molecular pharmacology},
  volume={56 1},
Doxorubicin and idarubicin are very effective anticancer drugs in the treatment of human hematological malignancies and solid tumors. These agents are well known topoisomerase II poisons; however, some anthracycline analogs recently have been shown to poison topoisomerase I. In the present work, we assayed novel disaccharide analogs and the parent drug, idarubicin, for their poisoning effects of human topoisomerase I and topoisomerases IIalpha and IIbeta. Drugs were evaluated with a DNA… CONTINUE READING


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