Topoisomerase inhibition by phenolic metabolites: a potential mechanism for benzene's clastogenic effects.

@article{Chen1995TopoisomeraseIB,
  title={Topoisomerase inhibition by phenolic metabolites: a potential mechanism for benzene's clastogenic effects.},
  author={Huaiyang Chen and David A. Eastmond},
  journal={Carcinogenesis},
  year={1995},
  volume={16 10},
  pages={2301-7}
}
Exposure to benzene, a human and animal carcinogen, results in the formation of structural chromosomal aberrations in the bone marrow and blood cells of animals and humans. The mechanisms underlying these clastogenic effects are unknown. Inhibition of enzymes involved in DNA replication and repair, such as topoisomerase enzymes, by the metabolites of benzene represents a potential mechanism for the formation of chromosomal aberrations. To test this hypothesis, the inhibitory effects of various… CONTINUE READING
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