Topoisomerase Inhibitors

@article{Sinha2012TopoisomeraseI,
  title={Topoisomerase Inhibitors},
  author={Birandra Kumar Sinha},
  journal={Drugs},
  year={2012},
  volume={49},
  pages={11-19}
}
SummaryThe nuclear enzymes topoisomerase I and II are critical for DNA function and cell survival, and recent studies have identified these enzymes as cellular targets for several clinically active anticancer drugs. Topoisomerase II inhibitors (anthracyclines, epipodophyllotoxins, etc.) are active against several types of tumours. However, treatment with these drugs often results in the development of the multi-drug resistance. Because topoisomerase II-active drugs have several different modes… Expand
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