Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance.

Abstract

Interactions between retinoic acid (RA) receptor alpha (RARalpha) and coregulators play a key role in coordinating gene transcription and myeloid differentiation. In patients with acute promyelocytic leukemia (APL), the RARalpha gene is fused with the promyelocytic leukemia (PML) gene via the t(15;17) translocation, resulting in the expression of a PML… (More)
DOI: 10.1128/MCB.01576-07

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@article{McNamara2008TopoisomeraseIN, title={Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance.}, author={Suzan McNamara and Hongling Wang and Nessrine Hanna and Wilson H. Miller}, journal={Molecular and cellular biology}, year={2008}, volume={28 6}, pages={2066-77} }