Topoisomerase II isoforms are required for HIV-1 reverse transcription


Background Human topoisomerase II is present in two forms 170kDa a and 180 kDa b isoform. Early reports have indicated that the topoII poisons and antisense RNA can block viral replication. The objective of present study is to evaluate specific requirement of topoII isomerases in promoting HIV replication and to characterize the HIV-1 replication intermediates to study molecular action of the topoII a or/and b isoforms.

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@inproceedings{Sunnam2012TopoisomeraseII, title={Topoisomerase II isoforms are required for HIV-1 reverse transcription}, author={Lokeswara Balakrishna Sunnam and N. Satyanarayana and Anand K. Kondapi}, year={2012} }