Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers

@article{Hsieh2014TopoisomeraseII,
  title={Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers},
  author={Meng-Hsun Hsieh and Cheng-Hui Tsai and Chuan-Chuan Lin and Tsai-Kun Li and Ting-Wei Hung and Li-Te Chang and Ling-Wei Hsin and Shu-Chun Teng},
  journal={Cellular and Molecular Life Sciences},
  year={2014},
  volume={72},
  pages={1825-1837}
}
Telomere maintenance is required for chromosome stability, and telomeres are typically elongated by telomerase following DNA replication. In both tumor and yeast cells that lack telomerase, telomeres are maintained via an alternative recombination mechanism. Previous studies have indicated that yeast Sgs1 and Top3 may work together to remove highly negative supercoils that are generated from recombination. However, the mechanism by which cells eradicate highly positive supercoils during… CONTINUE READING
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