Topoisomerase II drives DNA transport by hydrolyzing one ATP.

  title={Topoisomerase II drives DNA transport by hydrolyzing one ATP.},
  author={Cheryl L. Baird and Timothy T. Harkins and Shaunna K Morris and Janet E. Lindsley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 24},
DNA topoisomerase II is a homodimeric molecular machine that couples ATP usage to the transport of one DNA segment through a transient break in another segment. In the presence of a nonhydrolyzable ATP analog, the enzyme is known to promote a single turnover of DNA transport. Current models for the enzyme's mechanism based on this result have hydrolysis of two ATPs as the last step, used only to reset the enzyme for another round of reaction. Using rapid-quench techniques, topoisomerase II… CONTINUE READING
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DNA Topoisomerases: Topoisomerase Targeting Drugs (Academic, San Diego)

  • L. F. Liu
  • 1994

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