Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.

@article{Sordet2008TopoisomeraseIR,
  title={Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.},
  author={Olivier Sordet and Abby R. Goldman and Christophe E. Redon and St{\'e}phanie Solier and V Ashutosh Rao and Yves Pommier},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 34},
  pages={
          23200-8
        }
}
Topoisomerase I (Top1) is known to relax DNA supercoiling generated by transcription, replication, and chromatin remodeling. However, it can be trapped on DNA as cleavage complexes (Top1cc) by oxidative and carcinogenic DNA lesions, base damage, and camptothecin treatment. We show here that Top1 is also functionally involved in death receptor-induced programmed cell death. In cells exposed to TRAIL or Fas ligand, Top1cc form at the onset of apoptosis. Those apoptotic Top1cc are prevented by… CONTINUE READING
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