Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases.

@article{Boonsong2002TopoisomeraseIP,
  title={Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases.},
  author={Attasit Boonsong and Stephanie Curran and J. A. Mckay and James Richard Cassidy and Graeme I Murray and Howard L. McLeod},
  journal={Human pathology},
  year={2002},
  volume={33 11},
  pages={
          1114-9
        }
}
Topoisomerase I (topo I) is an important target for the treatment of malignant disease, especially colorectal cancer. Because there is little information on the expression of topo I in colorectal tumors, this study evaluated and characterized topo I protein expression in primary colorectal cancer and lymph node metastases and studied the association between topo I protein expression and clinicopathologic data, p53 status, and proliferating cell nuclear antigen (PCNA) status… CONTINUE READING
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