Topoisomerase I activity and cellular response to radiation in Chinese hamster cells.

@article{Zanier1996TopoisomeraseIA,
  title={Topoisomerase I activity and cellular response to radiation in Chinese hamster cells.},
  author={Romina Zanier and Rosella De Salvia and Mario Fiore and Francesca Degrassi},
  journal={International journal of radiation biology},
  year={1996},
  volume={70 3},
  pages={251-9}
}
The aim of the present study was to investigate the synergistic potential of the combination of camptothecin, a specific inhibitor of topoisomerase I, and radiation in the the induction of chromosome aberrations and cell cycle delay in actively proliferating mammalian cells. Synergistic effects of the combined treatments were obtained for induced frequencies of aberrations in exponentially growing Chinese hamster ovary cells. The potentiating effects were more pronounced for aberrations of the… CONTINUE READING