Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis.

@article{Sordet2004TopoisomeraseIC,
  title={Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis.},
  author={Olivier Sordet and Zhiyong Liao and Hong Liu and Sebastian Antony and Ellen Virginia Stevens and Glenda B. Kohlhagen and Haiqing Fu and Yves Pommier},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 32},
  pages={
          33968-75
        }
}
Topoisomerase I is an essential enzyme that relaxes DNA supercoiling by forming covalent DNA cleavage complexes, which are normally transient. Topoisomerase I-DNA complexes can be trapped by anticancer drugs (camptothecins) as well as by endogenous and exogenous DNA lesions. We show here that arsenic trioxide (a potent inducer of apoptosis that induces the intracellular accumulation of reactive oxygen species and targets mitochondria) induces cellular topoisomerase I cleavage complexes. Bcl-2… CONTINUE READING
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