Topography of cocaine-induced gene regulation in the rat striatum: relationship to cortical inputs and role of behavioural context.

@article{Willuhn2003TopographyOC,
  title={Topography of cocaine-induced gene regulation in the rat striatum: relationship to cortical inputs and role of behavioural context.},
  author={Ingo Willuhn and Weiwen Sun and Heinz Steiner},
  journal={The European journal of neuroscience},
  year={2003},
  volume={17 5},
  pages={1053-66}
}
Psychostimulants alter gene expression in projection neurons of the striatum, and such neuroplasticity is implicated in drug addiction and dependence. Evidence indicates that excitatory inputs from the cortex and thalamus are critical for these molecular changes. In the present study, we determined the topography of cocaine-induced changes in gene expression in the rat striatum and investigated whether these molecular alterations are associated with particular cortical inputs. Acute induction… CONTINUE READING

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The rate of cocaine administration alters gene regulation and behavioral plasticity: implications for addiction.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2004
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