Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor.

@article{Clifford2000TopographicalEO,
  title={Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor.},
  author={Jeremiah J. Clifford and Alessandro Usiello and Daniela Vallone and Anthony Kinsella and Emiliana Borrelli and John L Waddington},
  journal={Neuropharmacology},
  year={2000},
  volume={39 3},
  pages={
          382-90
        }
}
The phenotype of spontaneous and dopamine D2-like agonist-induced behaviour was assessed topographically in a line of mice with targeted gene deletion of the D1 receptor. An ethologically-based, rapid time-sampling behavioural check-list technique was used to resolve and quantify all behaviours in the natural repertoire of the mouse. Relative to wildtypes [D2+/+], D2-null [D2-/-] mice evidenced over a 1 h period of initial exploration modest but significant reductions in locomotion, grooming… CONTINUE READING
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