Topiramate titration and tolerability.

  title={Topiramate titration and tolerability.},
  author={Victor Biton and Keith R. Edwards and Georgia D. Montouris and J. Chris Sackellares and Cynthia L. Harden and Marc Kamin},
  journal={The Annals of pharmacotherapy},
  volume={35 2},
OBJECTIVE To evaluate the tolerability and efficacy of two titration rates for topiramate initiated as adjunctive therapy in adults with partial-onset seizures, with or without secondary generalization, in a multicenter, double-blindtrial. METHODS After a two-week baseline phase, 188 patients were randomized to either a 50/50 titration schedule (initial dosage 50 mg/d increased in 50-mg/d increments at weekly intervals; n = 95) or to a 100/200 titration schedule (initial dosage 100 mg/d… CONTINUE READING

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