Topiramate reduces levodopa-induced dyskinesia in the MPTP-lesioned marmoset model of Parkinson's disease.

@article{Silverdale2005TopiramateRL,
  title={Topiramate reduces levodopa-induced dyskinesia in the MPTP-lesioned marmoset model of Parkinson's disease.},
  author={Monty Silverdale and Shannon Nicholson and Alan R. Crossman and Jonathan Michael Brotchie},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2005},
  volume={20 4},
  pages={403-9}
}
Overactive AMPA receptor-mediated transmission may be involved in the pathogenesis of levodopa-induced dyskinesia. The mechanism of action of the anticonvulsant drug topiramate involves attenuation of AMPA receptor-mediated transmission. In this study, the potential antidyskinetic action of topiramate was examined in the MPTP-lesioned marmoset model of Parkinson's disease and levodopa-induced dyskinesia. Topiramate significantly reduced levodopa-induced dyskinesia, without affecting the… CONTINUE READING