Topiramate kinetics during delivery, lactation, and in the neonate: preliminary observations.

  title={Topiramate kinetics during delivery, lactation, and in the neonate: preliminary observations.},
  author={Inger K Ohman and Sigurd Vitols and Gerhard J. Luef and Birgitta A S{\"o}derfeldt and Torbjōrn Tomson},
  volume={43 10},
PURPOSE To study the pharmacokinetics of topiramate (TPM) during delivery, lactation, and in the neonate. METHODS TPM concentrations in plasma and breast milk were measured with fluorescence polarization immunoassay (FPIA) in five women with epilepsy treated with TPM during pregnancy and lactation. Blood samples were obtained at delivery from mothers, from the umbilical cord, and from the newborns on three occasions (24, 48, and 72 h) after delivery. Blood and breast milk also were collected… CONTINUE READING

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