Topiramate in refractory partial-onset seizures in children, adolescents and young adults: a multicentric open trial

  title={Topiramate in refractory partial-onset seizures in children, adolescents and young adults: a multicentric open trial},
  author={G. Coppola and G. Caliendo and Maria Maddalena Terracciano and Salvatore Buono and A. Pascotto},
  journal={Epilepsy Research},
  • G. Coppola, G. Caliendo, +2 authors A. Pascotto
  • Published 2001
  • Medicine
  • Epilepsy Research
  • PURPOSE This study was to evaluate the efficacy and safety of topiramate (TPM) in refractory partial epilepsy in children, adolescents and young adults. METHODS We performed a prospective open label add-on study in 55 patients (age 2-30 years, mean 15 years) with refractory partial seizures. Topiramate was added to one or two other baseline drugs and the efficacy was rated according to seizure type and frequency. RESULTS TPM was initiated at a daily dose of 0.5-1 mg/kg, followed by a 2-week… CONTINUE READING
    41 Citations
    Efficacy and Safety of Topiramate in Refractory Epilepsy of Childhood
    • 28
    Long-Term Open-Label Study of Adjunctive Topiramate in Infants With Refractory Partial-Onset Seizures
    • 12


    Clinical experiences with topiramate in children with intractable epilepsy.
    • P. Uldall, J. Buchholt
    • Medicine
    • European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
    • 1999
    • 39
    Topiramate in intractable childhood onset epilepsy--a cautionary note.
    • 32
    • PDF
    Topiramate for drug-resistant epilepsies.
    • 26
    A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures
    • 281
    Topiramate use in pediatric patients.
    • T. Glauser
    • Medicine
    • The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
    • 1998
    • 17
    • PDF
    Clinical Efficacy of Topiramate as Add‐On Therapy in Refractory Partial Epilepsy: The European Experience
    • 29
    Preliminary Open‐Label Experience with Topiramate in Primary Generalized Seizures
    • 28