Topiramate in pregnancy

@article{Hunt2008TopiramateIP,
  title={Topiramate in pregnancy},
  author={S. Hunt and A. Russell and W. Smithson and L. Parsons and I. Robertson and R. Waddell and B. Irwin and P. Morrison and J. Morrow and J. Craig},
  journal={Neurology},
  year={2008},
  volume={71},
  pages={272 - 276}
}
Objectives: Topiramate (Topamax®) is licensed to be used, either in monotherapy or as adjunctive treatment, for generalized tonic clonic seizures or partial seizures with or without secondary generalization and for prevention of migraine. The safety of topiramate in human pregnancy is largely unknown. Here we report on our experience of pregnancies exposed to topiramate. Methods: This study is part of a prospective, observational, registration and follow-up study. Suitable cases are women with… Expand
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References

SHOWING 1-10 OF 26 REFERENCES
Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register
TLDR
Only 4.2% of live births to women with epilepsy had an MCM, and polytherapy exposure was greater than for monotherapy exposure, and carbamazepine was associated with the lowest risk of MCM. Expand
Oxcarbazepine in pregnancy: clinical experience in Argentina
TLDR
The multicenter clinical experience in Argentina of pregnant women with epilepsy receiving AEDs is reported, adding to the growing experience with AED therapy in pregnantWomen with epilepsy. Expand
Congenital malformations due to antiepileptic drugs
TLDR
The results indicate that the increased incidence of congenital malformations was caused primarily by AEDs, suggesting that mal Formations can be prevented by improvements in drug regimen, and by avoiding polypharmacy and high levels of VPA in the treatment of epileptic women of childbearimg age. Expand
Levetiracetam in pregnancy: Preliminary experience from the UK Epilepsy and Pregnancy Register
TLDR
It is not known whether the antiepileptic drug levetiracetam can be used safely in human pregnancy, but three of 117 exposed pregnancies had an MCM and all 3 were exposed to other AEDs. Expand
Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy
TLDR
There is a dose-effect relationship for FM and exposure to VPA during the first trimester of pregnancy, with higher doses of VPA associated with a significantly greater risk than with lower doses or with other AEDs. Expand
Antiepileptic drug regimens and major congenital abnormalities in the offspring
TLDR
Most antiepileptic drug regimens were associated with an increased risk of major congenital abnormalities in the offspring, in particular valproate (dose–response relationship) and carbamazepine monotherapy, benzodiazepines in polytherapy, and caffeine comedication in combinations with phenobarbital. Expand
Levetiracetam monotherapy during pregnancy: a case series
  • L. Long
  • Medicine
  • Epilepsy & Behavior
  • 2003
TLDR
This case series summarizes the clinical outcomes of three women with epilepsy, all of whom took levetiracetam as monotherapy during pregnancy. Expand
Birth prevalence of cryptorchidism and hypospadias in northern England, 1993–2000
TLDR
The birth prevalence of cryptorchidism and hypospadias in the northern region of England during the period 1993–2000 was investigated and there was an apparent decline in the prevalence of surgically corrected cryptorhideism that may reflect a decrease in the prevalences of the condition or may be due to a decreases in the rate of surgical intervention. Expand
Pregnancies of Women with Epilepsy: A Population‐Based Study in Iceland
Summary: Purpose: Women with epilepsy who become pregnant are commonly considered to be at high risk for complications during pregnancy or delivery. The offspring are also considered o have increasedExpand
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