Topiramate in migraine prevention: results of a large controlled trial.

  title={Topiramate in migraine prevention: results of a large controlled trial.},
  author={Stephen David Silberstein and Walter Neto and Jennifer Schmitt and David Jacobs},
  journal={Archives of neurology},
  volume={61 4},
BACKGROUND Open-label trials and small controlled studies report topiramate's efficacy in migraine prevention. OBJECTIVE To assess the efficacy and safety of topiramate as a migraine-preventive therapy. DESIGN A 26-week, randomized, double-blind, placebo-controlled study. SETTING Outpatient treatment at 49 US clinical centers. Patients Patients were aged 12 to 65 years, had a 6-month International Headache Society migraine history, and experienced 3 to 12 migraines per month, but had 15… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 162 extracted citations

Current and emerging therapies for migraine prevention and treatment.

Handbook of clinical neurology • 2010
View 3 Excerpts
Highly Influenced

Clinical pharmacology of topiramate in migraine prevention.

Expert opinion on drug metabolism & toxicology • 2011
View 10 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 18 references

Topiramate in the treatment of bulimia nervosa: a randomized, double-blind, placebo-controlled trial

SP Hoopes, FW Reimherr, DW Hedges
J Clin Psychiatry • 2003

Efficacy of topiramate in migraine prophylaxis: a retrospective chart analysis

RL Von Seggern, LK Mannix, JU. Adelman
Headache • 2002

Headache in Clinical Practice

SD Silberstein, RB Lipton, PJ. Goadsby
View 2 Excerpts

Similar Papers

Loading similar papers…