Topiramate in migraine prevention: results of a large controlled trial.

@article{Silberstein2004TopiramateIM,
  title={Topiramate in migraine prevention: results of a large controlled trial.},
  author={Stephen David Silberstein and Walter Neto and Jennifer Schmitt and David Jacobs},
  journal={Archives of neurology},
  year={2004},
  volume={61 4},
  pages={490-5}
}
BACKGROUND Open-label trials and small controlled studies report topiramate's efficacy in migraine prevention. OBJECTIVE To assess the efficacy and safety of topiramate as a migraine-preventive therapy. DESIGN A 26-week, randomized, double-blind, placebo-controlled study. SETTING Outpatient treatment at 49 US clinical centers. Patients Patients were aged 12 to 65 years, had a 6-month International Headache Society migraine history, and experienced 3 to 12 migraines per month, but had 15… CONTINUE READING
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