Topiramate for smoking cessation.


Due to its AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)/kainate antagonism, topiramate would be particularly interesting in addiction treatment. Flexible-dose topiramate was prescribed to 13 smokers (10 smokers who wanted to stop smoking, and three who received topiramate for other reasons). Six out of 13 smokers were abstinent at 2 months and two more subjects had reduced their cigarette consumption by >50%. With one exception, temporary reduction of the number of smoked cigarettes preceded definitive abstinence at month 2. Three more subjects who achieved a momentary reduction had, however, to interrupt the treatment due to intolerable side-effects. Controlled trials are needed to confirm these preliminary observations.


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@article{Khazaal2006TopiramateFS, title={Topiramate for smoking cessation.}, author={Yasser Khazaal and Jacques Cornuz and Romain Bilancioni and Daniele Zullino}, journal={Psychiatry and clinical neurosciences}, year={2006}, volume={60 3}, pages={384-8} }