Topiramate for Alcohol Dependence

@article{Olmsted2008TopiramateFA,
  title={Topiramate for Alcohol Dependence},
  author={C L Olmsted and Denise R Kockler},
  journal={Annals of Pharmacotherapy},
  year={2008},
  volume={42},
  pages={1475 - 1480}
}
Objective: To evaluate the evidence for the use of topiramate for alcohol dependence. Data Sources: MEDLINE (l 966-June 2008) and Cochrane Database (2008, Issue 1) searches were conducted using the search terms alcohol dependence and topiramate. Bibliographies of selected articles were examined for additional data sources. Study Selection and Data Extraction: English-language, randomized, controlled trials evaluating topiramate for treatment of alcohol dependence in humans were selected for… Expand
Topiramate in Alcohol Use Disorders: Review and Update
TLDR
Topiramate, within the dosage range of 75–300 mg/day, could be considered as a first-line treatment option for the management of AUDs and appears to be safe and well-tolerated, especially in light of very recent findings. Expand
A meta-analysis of topiramate's effects for individuals with alcohol use disorders.
TLDR
Topiramate can be a useful tool in the treatment of AUDs and its efficacy seems to be of somewhat greater magnitude than that of the most commonly prescribed medications for AUDs (naltrexone and acamprosate). Expand
Anticonvulsants for alcohol dependence.
TLDR
The primary aim of the review was to assess the benefits/risks of anticonvulsants for the treatment of alcohol dependence and to confirm the direction of results was confirmed by subgroup analyses for topiramate and partially for gabapentin and valproate. Expand
Treatment of alcohol dependence with low-dose topiramate: an open-label controlled study
TLDR
Low-dose topiramate as an adjunct to psychotherapeutic treatment is well tolerated and effective in reducing alcohol craving, as well as symptoms of depression and anxiety, present during the early phase of alcohol withdrawal. Expand
Topiramate for Use in Adult Migraine Prophylaxis
TLDR
Topiramate is an appropriate first-line drug to consider for prevention of adult migraine and its safety profile appears to be as good as or better than that of other prophylactic agents. Expand
Prescription of topiramate to treat alcohol use disorders in the Veterans Health Administration
TLDR
Predictors of topiramate prescription were female sex, young age, alcohol dependence diagnoses, engagement in both mental health and addiction specialty care, and psychiatric comorbidity, which may underestimate the extent to which vets at specific facilities and overall are receiving pharmacotherapy for AUD. Expand
Pharmacotherapy for alcohol dependence: A stratified approach.
TLDR
This review provides a narrative regarding potential stratification techniques in pharmacological treatment of alcohol dependence, with a specific focus on typologies and pharmacogenetics, and discusses the basic background of stratified medicine. Expand
The role of topiramate and other anticonvulsants in the treatment of alcohol dependence: a clinical review.
TLDR
The role of topiramate and other anticonvulsants in the management of alcohol dependence is looked at, along with its proposed mechanism of action in alcohol dependence. Expand
New approved and emerging pharmacological approaches to alcohol use disorder: a review of clinical studies
TLDR
This review aims to synthesise literature for new approved and emerging pharmacotherapies for AUD and strategies for improving the translational pipeline include drug repurposing and utilisation of human acute laboratory models. Expand
Pharmacogenomics of alcohol addiction: Personalizing pharmacologic treatment of alcohol dependence
TLDR
It is anticipated that future implementation of pharmacogenomics in clinical practice will help personalize alcohol dependence drug treatment, and development personalized hospital pharmacology. Expand
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