Topiramate blocks kainate-evoked cobalt influx into cultured neurons.

@article{Skradski2000TopiramateBK,
  title={Topiramate blocks kainate-evoked cobalt influx into cultured neurons.},
  author={Shana L. Skradski and Henry S White},
  journal={Epilepsia},
  year={2000},
  volume={41 Suppl 1},
  pages={
          S45-7
        }
}
PURPOSE This study evaluated topiramate (TPM) antagonism of glutamate receptors activated by kainate. METHODS The ability of TPM (3-30 microM) to attenuate kainate (300 microM)-activated cobalt (Co2+) flux through nonselective cation channels permeable to Co2+, Mn2+, and Ca2+ into cultured cerebellar granule neurons [9-14 days in vitro (div)] was investigated. Results were compared with those obtained with the non-N-methyl-D-aspartate (non-NMDA) antagonist 6,7-dinitroquinoxalone-2,3-dione… CONTINUE READING
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