Topiramate augmentation of clozapine in schizophrenia: a double-blind, placebo-controlled study.

@article{Muscatello2011TopiramateAO,
  title={Topiramate augmentation of clozapine in schizophrenia: a double-blind, placebo-controlled study.},
  author={Maria Rosaria Anna Muscatello and Antonio Bruno and Gianluca Pandolfo and Umberto Mic{\`o} and Paolo Micali Bellinghieri and Giuseppe Scimeca and Massimo Cacciola and Domenica Campolo and Salvatore Settineri and Rocco Zoccali},
  journal={Journal of psychopharmacology},
  year={2011},
  volume={25 5},
  pages={667-74}
}
The persistence of psychotic, affective, cognitive, and psychosocial symptoms despite medications is commonly observed in schizophrenic patients. The present study was a 24-week double-blind, randomized, placebo-controlled trial aimed to explore the efficacy of topiramate add-on pharmacotherapy on clinical symptomatology and cognitive functioning in a sample of treatment-resistant schizophrenic patients receiving clozapine. After clinical and cognitive assessments were randomly allocated to… CONTINUE READING

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