• DOI:10.1016/S0920-1211(02)00103-1
Corpus ID: 24698326

Topiramate as add-on drug in children, adolescents and young adults with Lennox-Gastaut syndrome: an Italian multicentric study

@article{Coppola2002TopiramateAA,
  title={Topiramate as add-on drug in children, adolescents and young adults with Lennox-Gastaut syndrome: an Italian multicentric study},
  author={G. Coppola and G. Caliendo and P. Veggiotti and A. Romeo and A. Pascotto},
  journal={Epilepsy Research},
  year={2002},
  volume={51},
  pages={147-153}
}

G. Coppola, G. Caliendo, +2 authors A. Pascotto

Published 2002

Medicine

Epilepsy Research

The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. TPM was added to one or two other baseline drugs and the efficacy was rated according to seizure type and frequency. TPM was initiated at the daily dose of 0.5-1 mg/kg, followed by… CONTINUE READING

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