Topiramate Therapy in Alternating Hemiplegia of Childhood

  title={Topiramate Therapy in Alternating Hemiplegia of Childhood},
  author={A. Kasinathan and I. Sharawat and J. Sahu and N. Sankhyan},
  journal={The Indian Journal of Pediatrics},
To the Editor: In a recent publication from our centre, we had highlighted novel features in a child with Alternating hemiplegia of childhood (AHC) [1]. We would like to share our experience with the use of topiramate in the management of an another genetically confirmed child with the same disorder. A 14-mo-old girl presented with concerns of global developmental delay (6–8 mo) and paroxysmal episodes of tonic/dystonic spells of the neck and upper limb since three months of age. She was first… Expand
2 Citations
ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response
Assessment of the prevalence and efficacy of commonly used anti-epileptic-drugs (AEDs) in patients with ATP1A3 related seizures found the findings of treatment effectiveness in only 57% (or lower) of patients, and the non-existence of a clear first-line AED in ATP1 a3 related epilepsy stresses the need for further research. Expand


Alternating Hemiplegia of Childhood with Novel Features
To the Editor : Alternating hemiplegia of childhood (AHC) is a distinct clinical phenotype, characterized by infantile onset recurrent hemiplegic episodes, developmental delay, epilepsy, andExpand
Alternating hemiplegia of childhood.
The condition seems to be distinct from epilepsy, and the clinical features and poor outcome differentiate it from migraine. Expand
Topiramate: a new agent for patients with alternating hemiplegia of childhood.
Following treatment with topiramate, the frequency and duration of hemiplegic attacks significantly improved in all patients and additional symptoms such as seizures, migraine, involuntary movements, autonomic symptoms, and impaired mental development improved. Expand
Evidence of a non-progressive course of alternating hemiplegia of childhood: study of a large cohort of children and adults.
The results provide evidence that the natural history of alternating hemiplegia is highly variable and unpredictable for individual patients and did not find evidence to support a steadily progressive and degenerative course of the disorder when patients were analysed as a group. Expand
a new agent for pat i e n t s w i t h a l t e r n a t i n g h em i p l e g i a o f c h i l d hood
  • Neuropediatrics. 2006;37:229–33. 958 Indian J Pediatr
  • 2017
study of a large cohort of children and adults
  • Brain. 2010;133:3598–610. * Naveen Sankhyan 1 Pediatric Neurology and Neurodevelopment Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India Indian J Pediatr
  • 2017
Evidence of a nonprogressive course of alternating hemiplegia of childhood : study of a large cohort of children and adults
  • Brain
  • 2010
Topiramate: a new agent for pat i e n t s w i t h a l t e r n a t i n g h em i p l e g i a o f c h i l d hood
  • Neuropediatrics
  • 2006