Topiramate Therapy in Alternating Hemiplegia of Childhood

@article{Kasinathan2017TopiramateTI,
  title={Topiramate Therapy in Alternating Hemiplegia of Childhood},
  author={A. Kasinathan and I. Sharawat and J. Sahu and N. Sankhyan},
  journal={The Indian Journal of Pediatrics},
  year={2017},
  volume={84},
  pages={957-958}
}
To the Editor: In a recent publication from our centre, we had highlighted novel features in a child with Alternating hemiplegia of childhood (AHC) [1]. We would like to share our experience with the use of topiramate in the management of an another genetically confirmed child with the same disorder. A 14-mo-old girl presented with concerns of global developmental delay (6–8 mo) and paroxysmal episodes of tonic/dystonic spells of the neck and upper limb since three months of age. She was first… Expand
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To the Editor : Alternating hemiplegia of childhood (AHC) is a distinct clinical phenotype, characterized by infantile onset recurrent hemiplegic episodes, developmental delay, epilepsy, andExpand
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TLDR
The results provide evidence that the natural history of alternating hemiplegia is highly variable and unpredictable for individual patients and did not find evidence to support a steadily progressive and degenerative course of the disorder when patients were analysed as a group. Expand
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