Topiramate Protects Pericytes from Glucotoxicity: Role for Mitochondrial CA VA in Cerebromicrovascular Disease in Diabetes.

@article{Patrick2015TopiramatePP,
  title={Topiramate Protects Pericytes from Glucotoxicity: Role for Mitochondrial CA VA in Cerebromicrovascular Disease in Diabetes.},
  author={Ping H Patrick and Tulin Otamis Price and Ana L Diogo and Nader Sheibani and W. A. Banks and Gul N. Shah},
  journal={Journal of endocrinology and diabetes},
  year={2015},
  volume={2 2}
}
Hyperglycemia in diabetes mellitus causes oxidative stress and pericyte depletion from the microvasculature of the brain thus leading to the Blood-Brain Barrier (BBB) disruption. The compromised BBB exposes the brain to circulating substances, resulting in neurotoxicity and neuronal cell death. The decline in pericyte numbers in diabetic mouse brain and pericyte apoptosis in high glucose cultures are caused by excess superoxide produced during enhanced respiration (mitochondrial oxidative… CONTINUE READING