Topically applied substance P enhanced healing of open excision wound in rats.

@article{Kant2013TopicallyAS,
  title={Topically applied substance P enhanced healing of open excision wound in rats.},
  author={Vinay Kant and Anu Gopal and Dhirendra Kumar and Sadhan Bag and N. P. Kurade and Amit Kumar and Surendra Kumar Tandan and Dinesh Kumar},
  journal={European journal of pharmacology},
  year={2013},
  volume={715 1-3},
  pages={
          345-53
        }
}
Significant social and financial burden due to wounds need newer drugs/formulations to speed up the healing process. Substance P (SP), a neuropeptide, is associated with release of various cytokines and growth factors from inflammatory, epithelial and endothelial cells. In the present study, temporal effects of topically applied SP (10(-7)M in normal saline) were evaluated in the modulation of various cytokines and growth factors that participate in cutaneous wound healing. Gross examination of… CONTINUE READING

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