Topically Administered Ketamine Reduces Capsaicin-Evoked Mechanical Hyperalgesia

  title={Topically Administered Ketamine Reduces Capsaicin-Evoked Mechanical Hyperalgesia},
  author={R. P{\"o}yhi{\"a} and A. Vainio},
  journal={The Clinical Journal of Pain},
  • R. Pöyhiä, A. Vainio
  • Published 2006
  • Medicine
  • The Clinical Journal of Pain
  • Background:The n-methyl-d-aspartate receptor antagonists such as ketamine relieve chronic pain but their oral and parenteral use is limited by the adverse effects. Experimental studies indicate that the peripheral n-methyl-d-aspartate receptors are involved in nociception. Recent clinical findings suggest that ketamine gel alleviates neuropathic pain, but no placebo-controlled randomized studies are available on the neurosensory effects of ketamine gel in experimental neurogenic pain… CONTINUE READING
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