Topically Administered Ketamine Reduces Capsaicin-Evoked Mechanical Hyperalgesia

@article{Pyhi2006TopicallyAK,
  title={Topically Administered Ketamine Reduces Capsaicin-Evoked Mechanical Hyperalgesia},
  author={Reino P{\"o}yhi{\"a} and Anneli Vainio},
  journal={The Clinical Journal of Pain},
  year={2006},
  volume={22},
  pages={32-36}
}
Background:The n-methyl-d-aspartate receptor antagonists such as ketamine relieve chronic pain but their oral and parenteral use is limited by the adverse effects. Experimental studies indicate that the peripheral n-methyl-d-aspartate receptors are involved in nociception. Recent clinical findings suggest that ketamine gel alleviates neuropathic pain, but no placebo-controlled randomized studies are available on the neurosensory effects of ketamine gel in experimental neurogenic pain… 
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