Topically Administered Ketamine Reduces Capsaicin-Evoked Mechanical Hyperalgesia

@article{Pyhi2006TopicallyAK,
  title={Topically Administered Ketamine Reduces Capsaicin-Evoked Mechanical Hyperalgesia},
  author={R. P{\"o}yhi{\"a} and A. Vainio},
  journal={The Clinical Journal of Pain},
  year={2006},
  volume={22},
  pages={32-36}
}
  • R. Pöyhiä, A. Vainio
  • Published 2006
  • Medicine
  • The Clinical Journal of Pain
  • Background:The n-methyl-d-aspartate receptor antagonists such as ketamine relieve chronic pain but their oral and parenteral use is limited by the adverse effects. Experimental studies indicate that the peripheral n-methyl-d-aspartate receptors are involved in nociception. Recent clinical findings suggest that ketamine gel alleviates neuropathic pain, but no placebo-controlled randomized studies are available on the neurosensory effects of ketamine gel in experimental neurogenic pain… CONTINUE READING
    52 Citations

    Paper Mentions

    Observational Clinical Trial
    The purpose of this research study is to measure how much, if any, ketamine is absorbed into the blood stream after ketamine gel is applied to the skin. The investigators expect that the… Expand
    ConditionsNeuropathic Pain.
    Topical and Peripheral Ketamine as an Analgesic
    • 47
    • PDF
    Topical high-concentration (40%) menthol-somatosensory profile of a human surrogate pain model.
    • 42

    References

    SHOWING 1-10 OF 43 REFERENCES
    Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans.
    • 39
    Peripheral Analgesic Effects of Ketamine in Acute Inflammatory Pain
    • 89
    A Pilot Study Examining Topical Amitriptyline, Ketamine, and a Combination of Both in the Treatment of Neuropathic Pain
    • 98
    Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain.
    • 140