Topical zoledronic acid decreases micromotion induced bone resorption in a sheep arthroplasty model

Abstract

BACKGROUND Initial micromotion of a total hip replacement is associated with aseptic loosening. The use of bisphosphonates could be one way to reduce peri-implant bone resorption induced by micromotion. Bisphosphonates compounds are inhibitors of bone resorption. The aim of this study was to investigate whether local treatment with bisphosphonate would… (More)
DOI: 10.1186/s12891-017-1802-z

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