Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells.

@article{Galiano2004TopicalVE,
  title={Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells.},
  author={Robert D. Galiano and Oren M. Tepper and Catherine R Pelo and Kirit A Bhatt and Matthew J Callaghan and Nicholas M Bastidas and Stuart Bunting and Hope G Steinmetz and Geoffrey C. Gurtner},
  journal={The American journal of pathology},
  year={2004},
  volume={164 6},
  pages={1935-47}
}
Diminished production of vascular endothelial growth factor (VEGF) and decreased angiogenesis are thought to contribute to impaired tissue repair in diabetic patients. We examined whether recombinant human VEGF(165) protein would reverse the impaired wound healing phenotype in genetically diabetic mice. Paired full-thickness skin wounds on the dorsum of db/db mice received 20 microg of VEGF every other day for five doses to one wound and vehicle (phosphate-buffered saline) to the other. We… CONTINUE READING