Topical vanadate optimizes collagen organization within granulation tissue.

  title={Topical vanadate optimizes collagen organization within granulation tissue.},
  author={Duncan J D Mackay and Kurtis E. Moyer and Gregory C. Saggers and Roland L. Myers and Donald Roy Mackay and Heinrich Ehrlich},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  volume={11 3},
Systemic ingestion of vanadate, a nonspecific inhibitor of tyrosine phosphatases, doubles wound breaking strength, enhances the packing of collagen fibers, and prevents the appearance of myofibroblasts in granulation tissue. Will the local application of vanadate mimic the systemic effects? Pairs of polyvinyl alcohol sponges, each with a central reservoir and attached injection port, were subcutaneously implanted in rats. Daily, one implant received 0.2 ml of saline and the other received 0.2… CONTINUE READING

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