Topical triple-antibiotic ointment as a novel therapeutic choice in wound management and infection prevention: a practical perspective

  title={Topical triple-antibiotic ointment as a novel therapeutic choice in wound management and infection prevention: a practical perspective},
  author={Robert A. Bonomo and Peter S Van Zile and Qing Li and Kenneth M. Shermock and William G. McCormick and Bruce E Kohut},
  journal={Expert Review of Anti-infective Therapy},
  pages={773 - 782}
Triple-antibiotic ointment (TAO) is a safe and effective topical agent for preventing infections in minor skin trauma. The formulation contains neomycin, polymyxin B and bacitracin in a petrolatum base. TAO is active against the most common disease-causing pathogens found in wounds and on the skin and may be an attractive alternative to oral therapy in select circumstances. Resistance to TAO does not develop readily, and safety studies have shown that the risk of allergic sensitivity to TAO is… 

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Topical antibiotic treatment for uncomplicated skin and skin structure infections: review of the literature

Topical approaches may offer effective, localized, well-tolerated alternatives to the systemic regimen, however, their value in the management of uncomplicated skin infections is not yet clearly defined.

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For the treatment of chronic refractory wounds, thorough debridement followed by compound polymyxin B ointment topical application can reduce and control wound infection effectively and accelerate the process of wound repair.

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The hypothesis that the sponge prevents infection in cardiac surgical patients at increased risk for sternal wound infection is tested to test among US patients with diabetes, high body mass index, or both.

Effects of topical application of silver sulfadiazine cream, triple antimicrobial ointment, or hyperosmolar nanoemulsion on wound healing, bacterial load, and exuberant granulation tissue formation in bandaged full-thickness equine skin wounds.

None of the treatments resulted in more rapid wound closure, compared with that for untreated control wounds under the study conditions, and when treatment is warranted, TAO may help to limit EGT formation.

New Therapeutic Methods to Treat Infections Caused by The ESKAPE Pathogens

Three new antimicrobial therapies have been developed that may provide new strategies for the therapeutic intervention of extremely antibiotic resistant bacterial species.


Phenytoin (Healosol®) has a potent wound healing activity comparable to Bacitracin-Neomycin (Bivatracin®) and Oxytetracycline-Crystal violet (Oxy G®) in treatment of the oral lesions of FMD in cattle.

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

This work provides updated concepts of physiological mechanisms, the factors that can interfere, and updated treatments used in skin wound healing, including surgical procedures and non-surgical treatments such as topical formulations, dressings, or skin substitutes.

Novel Antimicrobial Peptides: Targeting Wound Infections Caused by ‘Superbugs’ Resistant to All Current Antibiotics

Next-generation polymyxin-like lipopeptides hold significant potential for the treatment of chronic wound infections caused by problematic Gram-negative ‘superbugs’.

Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments

Combination therapy improved upon the effects of either agent alone and was effective in the treatment of contemporary methamphetamine-susceptible, methicillin-resistant, and high-level mupirocin-resistant S. aureus strains.



Topical antibiotics in dermatology.

Topical antibiotics are safe and effective in certain conditions, but extensive use, especially in closed populations, may encourage the emergence of resistant bacteria.

Prospective evaluation of topical antibiotics for preventing infections in uncomplicated soft-tissue wounds repaired in the ED.

The use of topical antibiotics resulted in significantly lower infection rates than did the use of a petrolatum control, and BAC and NEO had the lowest wound infection rates.

Topical antibacterial agents.

Topical antibiotics and minor skin trauma.

It is concluded that topical antibiotic combinations are safe and effective and that allergic sensitization to neomycin is rare.

Topical antibiotics and minor skin trauma.

It is concluded that topical antibiotic combinations are safe and effective and systemic side effects occur only with improper massive exposure.

Topical and Systemic Therapy for Pyodermas

  • H. Dillon
  • Medicine, Biology
    International journal of dermatology
  • 1980
Clinical, epidemiologic, and bacteriologic features of skin infection that are of importance in influencing choices of therapy will be discussed and selected studies from the laboratory will be briefly reported.

Impact of Increasing Antimicrobial Resistance on Wound Management

Research is needed on the applicability of alternatives to antimicrobials in the management of patients with wound infections in order to reduce the future risk of antimicrobial resistance.

A newly formulated topical triple-antibiotic ointment minimizes scarring.

A randomized study of polymyxin B sulfate-bacitracin zinc-neomycin sulfate versus simple gauze-type dressings in dermabrasion wounds assessed the effects that each treatment had on scarring. Each of

Topical antibiotic irrigation in the prophylaxis of operative wound infections in orthopedic surgery.

The effectiveness of topical antibiotics has been shown well enough in vitro and in the surgical literature to justify strong consideration of their use in orthopedic procedures, and evidence to suggest that the more often an irrigant is used, the more effective it is in preventing infection.