Topical tretinoin for hair growth promotion.

  title={Topical tretinoin for hair growth promotion.},
  author={Gail S. Bazzano and Nia K Terezakis and Wesley K. Galen},
  journal={Journal of the American Academy of Dermatology},
  volume={15 4 Pt 2},
          880-3, 890-3

The additive effects of minoxidil and retinol on human hair growth in vitro.

It is found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.

Promotive Effect of Minoxidil Combined with All-trans Retinoic Acid (tretinoin) on Human Hair Growth in Vitro

The results suggest that minoxidil plus ATRA would additively enhance hair growth by mediating dual functions: the prolongation of cell survival by activating the Erk and Akt signaling pathways, and the prevention of apoptosis of DPCs and epithelial cells by increasing the ratio of Bcl-2/Bax and downregulating the expressions of P53 and P21.

Effect of retinoids on follicular cells.

Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

This is the first study to elucidate the interaction mechanism between topical minoxidil and retinoids and thus provides a pathway for the development of future androgenetic alopecia treatments.

Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla.

This study is the first to provide direct evidence that ATRA can indeed induce a catagen-like stage in human HF and suggests that this occurs, at least in part, via upregulation of TGF-beta2 in the DP.

Improvement in androgenetic alopecia (stage V) using topical minoxidil in a retinoid vehicle and oral finasteride.

A 6to f 2-month trial of topical minoxidil in an optimized retinoid vehicle applied twice per day and 5 mg of finasteride taken orally each day to optimize the opportunity for hair regrowth in a patient with advanced, extensive AGA using nonsurgical intervention.

Beard hair density increase. A possible role of topical tretinoin application?

A 30-year-old male came to the authors' attention complaining of residual acne scars on both cheeks, for which two sessions of 70% pH 2.2 glycolic acid peeling, spaced a month from each other, reported a significant increase in beard density bilaterally, up to a level he stated had never been able to reach before.

Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution

Percutaneous minoxidil absorption is enhanced by tretinoin as a result of increased stratum corneum permeability, and transepidermal water loss measurements, which are sensitive to changes in stratum Corneum function, were significantly increased with t retinoin.

Phytotherapeutic Interventions using Rodent Models of Hair Loss: Current Research and Future Strategy

Hair follicles are special additions to mammalian skin with intricate differentiation and growth characteristics. They constantly undergo cycles of regression and regeneration throughout the lifespan



Topical minoxidil for hair regrowth.

Topical minoxidil in early male pattern baldness.

Topical minoxidil therapy in hereditary androgenetic alopecia.

The most notable indicators for regrowth of hair were the number of indeterminate hairs initially present, the duration of baldness, and the size of the balding area.

Direct effects of minoxidil on epidermal cells in culture.

It is demonstrated that minoxidil can affect epidermal cells in culture by altering their growth pattern and phenotypic appearance.

The cutaneous safety of topical tretinoin.

Advances in the development of newer dosage forms and treatment regimens, together with expanded knowledge of the many factors which contribute to the problem, mean that there should be very few patients who cannot be treated with tretinoin.

Effects of vitamin A acid in skin: in vivo and in vitro studies.

Profound metabolic changes take place in keratinizing epithelia in the presence of retinoic acid. In vivo as well as in vitro the proliferative activity of epidermal cells is greatly enhanced.

Cellular retinoic acid- but not cellular retinol-binding protein is elevated in psoriatic plaques.

The results suggest for the first time a link between the levels of CRABP and the responsiveness of a nonneoplastic hyperproliferative tissue to systemic administration of retinoids in the human.

Allergic contact dermatitis to retinoic acid

Allergic reactions to dental impression materials have been reported by Cronin (1973), Nally & Storrs (1973) and by van Groeningen & Nater (1975). The last-mentioned authors described four patients

Structure and tissue distribution of some retinoid-binding proteins.

The finding that CRBP and CRABP, the two intracellular proteins, are homologous to each other, to a myelin protein, and to a fatty acid-binding protein may shed light on the functions of these proteins.

Minoxidil stimulates cutaneous blood flow in human balding scalps: pharmacodynamics measured by laser Doppler velocimetry and photopulse plethysmography.

Analysis of vital signs for days 1 and 2 revealed no systemic effect from treatment with minoxidil, suggesting that the blood flow stimulation was directly related to the topical application of minoxIDil.