Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity

@article{Wormser2002TopicalTW,
  title={Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity},
  author={U. Wormser and B. Brodsky and R. Reich},
  journal={Archives of Toxicology},
  year={2002},
  volume={76},
  pages={119-121}
}
  • U. Wormser, B. Brodsky, R. Reich
  • Published 2002
  • Chemistry, Medicine
  • Archives of Toxicology
  • Abstract. Recently we have shown that post-exposure treatment with povidone iodine (PI) protects against nitrogen and sulfur mustard-induced skin lesions. Since proteolytic activity is involved in skin damage caused by chemical irritants, we have studied the effect of iodine on mechlorethamine (HN2)-induced skin collagenolytic activities in the haired guinea pig model. The matrix metalloproteinase-9 (MMP-9) activity increased by 30, 46, 12 and 23% after 3, 24, 48 and 72 h of HN2 exposure… CONTINUE READING
    Topical nitrogen mustard exposure causes systemic toxic effects in mice.
    • 13

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 19 REFERENCES
    Putative roles of inflammation in the dermatopathology of sulfur mustard
    • 61
    Sulfur mustard-increased proteolysis followingin vitro andin vivo exposures
    • 30