Topical treatment with nerve growth factor for corneal neurotrophic ulcers.

  title={Topical treatment with nerve growth factor for corneal neurotrophic ulcers.},
  author={Alessandro Lambiase and Paolo Rama and Sergio Bonini and G Caprioglio and Luigi Aloe},
  journal={The New England journal of medicine},
  volume={338 17},
BACKGROUND Corneal neurotrophic ulcers associated with impairment of sensory innervation of the cornea may lead to loss of vision, and there is no effective treatment for these ulcers. We evaluated the effects of nerve growth factor in patients with this disorder. METHODS Twelve patients (14 eyes) with severe neurotrophic corneal ulcers associated with corneal anesthesia were treated with topical nerve growth factor 10 times daily for two days and then 6 times daily until the ulcers healed… CONTINUE READING
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