Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model.

@article{Kleinjan2013TopicalTT,
  title={Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model.},
  author={Alex Kleinjan and Menno van Nimwegen and Karolina Leman and Henk C. Hoogsteden and Bart M. Lambrecht},
  journal={Allergy},
  year={2013},
  volume={68 2},
  pages={204-12}
}
BACKGROUND Sphingosine-1-phosphate (S1P) plays a crucial role in homeostasis of the immune system by regulating lymphocyte recirculation and inflammatory cell recruitment. The levels of S1P are tightly controlled through regulated production and controlled breakdown by sphingosine-lyase (SL). The S1P analogue FTY720 has been developed as an immunosuppressant in transplantation and tested as a treatment for various inflammatory diseases. FTY720 exploits S1P biology by acting as a S1P1 and S1P 3… CONTINUE READING

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