Topical treatment by urea reduces epidermal hyperproliferation and induces differentiation in psoriasis.

@article{Hagemann1996TopicalTB,
  title={Topical treatment by urea reduces epidermal hyperproliferation and induces differentiation in psoriasis.},
  author={Isolde Hagemann and Ehrhardt Proksch},
  journal={Acta dermato-venereologica},
  year={1996},
  volume={76 5},
  pages={
          353-6
        }
}
The mechanisms of action of urea-containing ointments in the treatment of eczema, ichthyosis and psoriasis are only partly known and related to proteolysis and keratinolysis. In this study, we have examined the effects of topical urea on epidermal proliferation and differentiation in 10 patients with psoriasis. Plaque type lesions were treated for 2 weeks with an ointment containing 10% urea, with the vehicle alone, or left untreated. Clinical score, hydration of the stratum corneum… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Similar Papers

Loading similar papers…