Topical timolol, at conventional, unilateral doses causes bilateral ocular beta-blockade in rabbits.

@article{Woodward1987TopicalTA,
  title={Topical timolol, at conventional, unilateral doses causes bilateral ocular beta-blockade in rabbits.},
  author={David F. Woodward and Malcolm Dowling and Barbara Feldmann and Jiaqi Chen},
  journal={Experimental eye research},
  year={1987},
  volume={44 2},
  pages={319-29}
}
The studies described herein reveal that unilateral 0.3% and 1% doses of timolol produce marked beta-adrenoceptor blockade in treated and in contralateral eyes which did not receive timolol. This indicates that unilateral, conventional topical doses of timolol administered to rabbits cause bilateral ocular beta-adrenoceptor blockade. In addition, 0.1% and 1… CONTINUE READING