Topical therapies in the management of chronic rhinosinusitis: an evidence‐based review with recommendations

@article{Rudmik2013TopicalTI,
  title={Topical therapies in the management of chronic rhinosinusitis: an evidence‐based review with recommendations},
  author={Luke R Rudmik and Monica Y Hoy and Rodney J. Schlosser and Richard J. Harvey and Kevin C. Welch and Valerie J. Lund and Timothy L. Smith},
  journal={International Forum of Allergy \& Rhinology},
  year={2013},
  volume={3},
  pages={281 - 298}
}
Topical therapies have become an integral component in the management plan for chronic rhinosinusitis (CRS). Several topical therapy strategies have been evaluated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence‐based approach for the utilization of topical therapies in the management of CRS. 

Paper Mentions

Interventional Clinical Trial
Chronic rhinosinusitis (CRS) affects up to 12.5% of the US population and has a significant disease burden. The recommended medical management of CRS includes large-volume, low-pressure… Expand
ConditionsAllergic Rhinosinusitis, Chronic Eosinophilic Rhinosinusitis, Chronic Rhinosinusitis (Diagnosis)
InterventionDrug
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A comprehensive, up to date analysis of the literature concerning the medical management of Chronic rhinosinusitis is provided by summarizing the evidence in support of traditional medical therapies for the management of CRS in addition to highlighting novel medical therapies currently under investigation. Expand
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The purpose in this study was to evaluate the efficacy and safety of topical corticosteroid treatment in chronic rhinosinusitis. Expand
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The objective of this work was to review the literature concerning the distribution of topical therapeutics to the sinuses versus nasal cavity regarding: surgical state, delivery device, headExpand
A Practical Approach to Refractory Chronic Rhinosinusitis.
TLDR
A practical framework for clinical evaluation and treatment of refractory chronic rhinosinusitis is presented and Germane to discussion are emerging concepts in refractors that will likely have important implications in the near future. Expand
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  • N. Tan, A. Psaltis
  • Medicine
  • Current opinion in otolaryngology & head and neck surgery
  • 2019
TLDR
Topical steroids delivered in conjunction with saline nasal irrigation offer the best combination of treatments in CRS and should be considered a standard of care. Expand
Impact of continued medical therapy in patients with refractory chronic rhinosinusitis
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References

SHOWING 1-10 OF 86 REFERENCES
Impact of topical nasal steroid therapy on symptoms of nasal polyposis
TLDR
The objective of this study was to determine the impact of topical steroid therapy on nasal symptoms in patients with nasal polyposis. Expand
A meta‐analysis of topical amphotericin B for the treatment of chronic rhinosinusitis
TLDR
Some clinicians have employed topical antifungal therapy with amphotericin B (AMB), however, its efficacy has not been consistently supported by the literature. Expand
The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: A multicenter randomized controlled study
It has been suggested that an exaggerated immune response to fungi is crucial in the pathogenesis of chronic rhinosinusitis (CRS). Based on this rationale, the use of topical antifungalsExpand
What is the role of long‐term macrolide therapy in the treatment of recalcitrant chronic rhinosinusitis?
TLDR
Long-duration therapy with macrolide antibiotics for the treatment of recalcitrant chronic rhinosinusitis based on the unique anti-inflammatory properties of macrolides rather than a strict antibacterial effect is advocated. Expand
Topical Steroid for Chronic Rhinosinusitis without Polyps
  • M. Burton, M. Ryan, R. Rosenfeld
  • Medicine
  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2012
TLDR
A Cochrane Review finds good evidence to support therapeutic benefits with no increase in adverse events compared with placebo controls for Chronic Rhinosinusitis without Polyps. Expand
Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis
TLDR
Evaluation of the efficacy of postoperative topical sinonasal steroid irrigations for CRS of chronic rhinosinusitis finds devices delivering large volume with positive pressure allow better distribution to sinus mucosa. Expand
Nasal Lavage With Mupirocin for the Treatment of Surgically Recalcitrant Chronic Rhinosinusitis
TLDR
The efficacy and tolerability of topical mupirocin for the management of surgically recalcitrant chronic rhinosinusitis associated with Staphylococcus aureus infection is examined. Expand
Topical Antimicrobials in the Management of Chronic Rhinosinusitis: A Systematic Review
TLDR
Topical antibiotics appear effective in the management of CRS, but larger and better-designed randomized double-blind placebo-controlled trials are required to more fully evaluate this emerging modality of treatment. Expand
Macrolide Therapy for Chronic Rhinosinusitis
TLDR
There is limited scientific evidence to support the use of long-term macrolide therapy for chronic rhinosinusitis, and further clinical research is needed to determine whether there may be a subgroup effect based on the underlying inflammatory disease process. Expand
Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis.
TLDR
There is no evidence to support the use of either topical or systemic antifungal treatment in the management of CRS, according to a pooled meta-analysis of randomised, placebo-controlled trials. Expand
...
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5
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