Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial

@article{Esposito2007TopicalSA,
  title={Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial},
  author={Ciro Esposito and Antonella Centonze and Francesca Alicchio and Antonio Savanelli and Alessandro Settimi},
  journal={World Journal of Urology},
  year={2007},
  volume={26},
  pages={187-190}
}
ObjectivesTopical steroids have been advocated as an effective alternative treatment to circumcision in boys with phimosis. We evaluated the effectiveness of topical steroid therapy compared to a placebo neutral cream in 240 patients with phimosis.MethodsA prospective study was carried out over a 24-months period, on an out-patient basis on two groups of patients with phimosis. One-hundred twenty patients applied a steroid cream twice a day for 4 weeks, and another group of 120 pts used a… 
Topical corticosteroids for treating phimosis in boys.
TLDR
Although sub optimal reporting among the included studies meant that the size of the effect remains uncertain, corticosteroids appear to be a safe, less invasive first-line treatment option before undertaking surgery to correct phimosis in boys.
Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial.
TLDR
Betamethasone Valerate 0.1%, 0.2% and 1% in combination with Hyaluronidase had equally higher results than placebo in the treatment of phimosis in boys from three to ten years-old.
Is steroids therapy effective in treating phimosis? A meta-analysis
TLDR
Compared to the placebo or manual reduction method, the topical steroid therapy is more effective in the treatment of phimosis in children, although there is still controversy in the different type and dosage of steroid.
Efficacy of topical steroid therapy for phimosis treatment: a systematic review
TLDR
Topical steroid is effective in reducing the phimosis signs and symptoms, especially in patients who are younger and less than 3 years old, and should be conducted in Indonesia to determine the effectiveness.
The Management of Phimosis Seen after Circumcision with Thermocautery.
TLDR
There is no place for topical steroids in management of iatrogenic phimosis after thermocautery is observed, thus, early surgery is advised to avoid emotional stress.
Effect of Topical Steroid Treatment for Concealed Penis: Is It Managed Conservatively?
TLDR
Concealed penis is highly resistant to topical steroid treatment and should be corrected surgically, according to the results of the present study.
Topical corticosteroids for phimosis in children: a network meta-analysis of randomized clinical trials
TLDR
Topical methylprednisolone, hydrocortisone, and betamethasone were observed with better clinical resolution of phimosis compared to other corticosteroids and low-potency drugs like beclomethasone and clobetasol were not observed to be superior to either placebo or other drugs.
Bipolar scissors circumcision is a safe, fast, and bloodless procedure in children.
Editorial Comment from Dr Mohta to Circumcision with a novel disposable device in Chinese children: A randomized controlled trial
  • A. Mohta
  • Medicine
    International journal of urology : official journal of the Japanese Urological Association
  • 2013
TLDR
The Shenghuan technique seems to be a safer and quicker method for children’s circumcision with better cosmetic results compared with conventional techniques despite the disadvantages, such as longer duration of pain, difficulty of removal or long fall-off period of the device.
...
1
2
3
4
...

References

SHOWING 1-10 OF 20 REFERENCES
The conservative treatment of phimosis in boys.
TLDR
Treatment with 0.05% betamethasone cream is a simple and safe method for the treatment of phimosis in boys older than 3 years and strongly supports the saying, "The fortunate foreskin of an infant boy will usually be left well alone by everyone but its owner'.
Topical steroid treatment of phimosis in boys.
TLDR
The response rate was greater than 95% in patients who received topical steroid treatment in addition to improved hygiene, and the subgroup with a buried penis responded poorly to steroid, retraction and hygiene treatment.
Treatment of phimosis with topical steroids in 194 children.
TLDR
Topical steroids are becoming the standard conservative measure for treating phimosis, with an overall efficacy of 87%, and this study supports this trend.
The response of phimosis to local steroid application
TLDR
Local application of steroid ointment to the foreskin results in resolution of phimosis in the majority of cases, but if the foreskin has a circumferential white scar, it is slightly less likely to respond.
A nonsurgical approach to the treatment of phimosis: local nonsteroidal anti-inflammatory ointment application.
TLDR
Nonsteroidal anti-inflammatory ointment application for phimosis may be an alternative to surgery and steroid application.
Treatment of childhood phimosis with a moderately potent topical steroid
TLDR
A prospective study was conducted to determine whether comparable results could be achieved using a weaker steroid cream in the treatment of phimosis, and found that it was possible to achieve comparable results using a stronger steroid cream.
...
1
2
...