Topical retinoids in the treatment of photoaging

@article{Stefanaki2005TopicalRI,
  title={Topical retinoids in the treatment of photoaging},
  author={Christina Stefanaki and Alexander J. Stratigos and Andreas D. Katsambas},
  journal={Journal of Cosmetic Dermatology},
  year={2005},
  volume={4}
}
A large number of different substances comprise the family of retinoids, which are traditionally described as vitamin A derivatives. By exerting their action through nuclear and cytoplasmic receptors they may improve photoaging. Tretinoin is the best studied retinoid in the treatment of photoaging. Others such as isotretinoin, retinaldehyde, and tazarotene, although less well studied, have given promising results. 
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28 Citations

Retinoids in cosmeceuticals
TLDR
Retinaldehyde, which is fairly well tolerated, seems to be the most efficient cosmeceutical retinoid; it has significant efficiency toward oxidative stress, cutaneous bacterial flora, epidermis renewing, and photoaging.
Efficacy and safety of retinaldehyde 0.1% and 0.05% creams used to treat photoaged skin: A randomized double‐blind controlled trial
TLDR
Retinaldehyde (RAL) is the natural precursor of retinoic acid and can be used to treat photoaged skin and the safety profile is good.
Topical Retinoids in Skin Ageing: A Focused Update with Reference to Sun-Induced Epidermal Vitamin A Deficiency
TLDR
Topical natural retinoic acid precursors such as retinaldehyde or retinol are less irritant than acidic retinoids and may prevent epidermal vitamin A deficiency due to nutritional deficiency, exposure to sunlight or any condition leading to free radical production.
Biochemical properties of retinoid-converting enzymes and biotechnological production of retinoids
TLDR
The biochemical properties and active sites and reaction mechanisms of retinoid-converting enzymes in animals and bacteria, including retinol dehydrogenase, alcohol dehydrogen enzyme, aldo-keto reductase, and aldehyde dehydrogensase are reviewed.
Treatment modalities for hyperpigmented skin lesions: A brief overview
TLDR
An overview of treatment modalities available for hyperpigmented skin lesions including the importance of photoprotection, various types of brightening creams, suitable types of chemical peels, specific laser therapies targeted for skinhyperpigmentation, and surgery is provided.
Antiageing Mechanisms of a Standardized Supercritical CO2 Preparation of Black Jack (Bidens pilosa L.) in Human Fibroblasts and Skin Fragments
TLDR
The ability to stimulate extracellular matrix elements, increase growth factors, and modulate retinoid and rexinoid receptors provides a basis for the development of preparation containing BPE-CO2A as an antiageing/skin-repair agent.
Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients
TLDR
The results of the clinical study in acne patients revealed that F13G showed significantly higher efficacy when compared to marketed product, and the addition of cholesterol in the film hydration method significantly decreased the vesicle size, and increased the percentage of incorporation efficiency at (p < 0.05).
In Vitro Evaluations for a New Topical Anti-Aging Formulation
TLDR
The new gel product, based on hyaluronic acid, Vitamin E and Humulus lupulus, showed a good efficacy as anti-aging effect reducing the oxidative damages derived by the action of ROS, moreover stimulating the synthesis of one of the components of the connective tissue, the collagen.
Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors.
Cosmeceuticals: practical applications.
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