Topical retinoids in the treatment of photoaging

  title={Topical retinoids in the treatment of photoaging},
  author={Christina Stefanaki and Alexander J. Stratigos and Andreas D. Katsambas},
  journal={Journal of Cosmetic Dermatology},
A large number of different substances comprise the family of retinoids, which are traditionally described as vitamin A derivatives. By exerting their action through nuclear and cytoplasmic receptors they may improve photoaging. Tretinoin is the best studied retinoid in the treatment of photoaging. Others such as isotretinoin, retinaldehyde, and tazarotene, although less well studied, have given promising results. 
Retinoids in cosmeceuticals
Retinaldehyde, which is fairly well tolerated, seems to be the most efficient cosmeceutical retinoid; it has significant efficiency toward oxidative stress, cutaneous bacterial flora, epidermis renewing, and photoaging.
Efficacy and safety of retinaldehyde 0.1% and 0.05% creams used to treat photoaged skin: A randomized double‐blind controlled trial
Retinaldehyde (RAL) is the natural precursor of retinoic acid and can be used to treat photoaged skin and the safety profile is good.
Topical Retinoids in Skin Ageing: A Focused Update with Reference to Sun-Induced Epidermal Vitamin A Deficiency
Topical natural retinoic acid precursors such as retinaldehyde or retinol are less irritant than acidic retinoids and may prevent epidermal vitamin A deficiency due to nutritional deficiency, exposure to sunlight or any condition leading to free radical production.
Biochemical properties of retinoid-converting enzymes and biotechnological production of retinoids
The biochemical properties and active sites and reaction mechanisms of retinoid-converting enzymes in animals and bacteria, including retinol dehydrogenase, alcohol dehydrogen enzyme, aldo-keto reductase, and aldehyde dehydrogensase are reviewed.
Treatment modalities for hyperpigmented skin lesions: A brief overview
An overview of treatment modalities available for hyperpigmented skin lesions including the importance of photoprotection, various types of brightening creams, suitable types of chemical peels, specific laser therapies targeted for skinhyperpigmentation, and surgery is provided.
Antiageing Mechanisms of a Standardized Supercritical CO2 Preparation of Black Jack (Bidens pilosa L.) in Human Fibroblasts and Skin Fragments
The ability to stimulate extracellular matrix elements, increase growth factors, and modulate retinoid and rexinoid receptors provides a basis for the development of preparation containing BPE-CO2A as an antiageing/skin-repair agent.
Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients
The results of the clinical study in acne patients revealed that F13G showed significantly higher efficacy when compared to marketed product, and the addition of cholesterol in the film hydration method significantly decreased the vesicle size, and increased the percentage of incorporation efficiency at (p < 0.05).
In Vitro Evaluations for a New Topical Anti-Aging Formulation
The new gel product, based on hyaluronic acid, Vitamin E and Humulus lupulus, showed a good efficacy as anti-aging effect reducing the oxidative damages derived by the action of ROS, moreover stimulating the synthesis of one of the components of the connective tissue, the collagen.
Cosmeceuticals: practical applications.


Retinoic acid receptors and topical acne therapy: establishing the link between gene expression and drug efficacy.
Following the success and widespread application of prescription-based topical retinoids used for acne and other skin disorders and retinol as a component of various cosmetics, little was known about the mechanism of action of these compounds until the last decade.
Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams.
The separation between clinical improvement and irritation suggests that mechanisms other than irritation dominate tretinoin-induced repair of photoaging in humans.
Treatment of photoaged skin with topical tretinoin.
  • A. Kligman, J. Leyden
  • Medicine
    Skin pharmacology : the official journal of the Skin Pharmacology Society
  • 1993
Once-daily application of tretinoin to photodamaged facial skin for 0-12 months results in substantial clinical and histologic improvement and the sum of changes is toward more youthful skin.
Topical tretinoin for photoaged skin.
Topical retinaldehyde on human skin: biologic effects and tolerance.
It is indicated that topical retinaldehyde has biologic activity and is well tolerated on human skin and allowed prolonged use in patients with inflammatory dermatoses.
Topical tretinoin for treatment of photodamaged skin. A multicenter study.
Clinical and histologic effects of a new emollient cream formulation of topical tretinoin at concentrations of 0.05% and 0.01% provide independent evidence supporting clinical improvement and side effects were usually mild and well tolerated.
Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation.
The data demonstrate that ROL application produces trace erythema not significantly different from vehicle, whereas RA causes ery thema, and does not significantly increase RA levels, compatible with the idea that R OL may be a prohormone of RA.
Topical retinoic acid for treatment of solar damage
There were significant improvements in fine wrinkling around the eyes, crease lines around the mouth and cheeks, wrinkling on the dorsum of the hands and yellow discoloration after 12 weeks of tretinoin cream treatment.