Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial.

  title={Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial.},
  author={C K Kimbrough-Green and Christopher Griffiths and Lina Finkel and Ted A. Hamilton and S M Bulengo-Ransby and Charles N. Ellis and John J. Voorhees},
  journal={Archives of dermatology},
  volume={130 6},
BACKGROUND AND DESIGN Melasma is an acquired, masklike, facial hyperpigmentation. The pathogenesis and treatment of melasma in black (African-American) patients is poorly understood. We investigated the efficacy of topical 0.1% all-trans-retinoic acid (tretinoin) in the treatment of melasma in black patients. Twenty-eight of 30 black patients with melasma completed a 10-month, randomized, vehicle-controlled clinical trial in which they applied either 0.1% tretinoin or vehicle cream daily to the… CONTINUE READING

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