Topical photodynamic treatment with poly-l-lysine–chlorin p6 conjugate improves wound healing by reducing hyperinflammatory response in Pseudomonas aeruginosa-infected wounds of mice

@article{Sahu2012TopicalPT,
  title={Topical photodynamic treatment with poly-l-lysine–chlorin p6 conjugate improves wound healing by reducing hyperinflammatory response in Pseudomonas aeruginosa-infected wounds of mice},
  author={Khageswar Sahu and Mrinalini Sharma and Harsha Bansal and Alok Dube and Pradeep K Gupta},
  journal={Lasers in Medical Science},
  year={2012},
  volume={28},
  pages={465-471}
}
We report the results of our investigations on the effect of antimicrobial photodynamic treatment (APDT) with poly-lysine-conjugated chlorin p6 (pl–cp6) on proinflammatory cytokine expression and wound healing in a murine excisional wound model infected with Pseudomonas aeruginosa. Treatment of infected wounds with pl–cp6 and light doses of 60 and 120 J/cm2 reduced the bacterial load by ~1.5 and 2.0 log, respectively, after 24 h. The treated wounds healed ~5 days earlier as compared to… CONTINUE READING
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