Topical photodynamic therapy of murine non-melanoma skin carcinomas with aluminum phthalocyanine chloride and a diode laser: pharmacokinetics, tumor response and cosmetic outcomes.

@article{Kyriazi2008TopicalPT,
  title={Topical photodynamic therapy of murine non-melanoma skin carcinomas with aluminum phthalocyanine chloride and a diode laser: pharmacokinetics, tumor response and cosmetic outcomes.},
  author={Maria Kyriazi and Eleni Alexandratou and Dido Yova and Michail Rallis and Tilmann Trebst},
  journal={Photodermatology, photoimmunology & photomedicine},
  year={2008},
  volume={24 2},
  pages={87-94}
}
BACKGROUND/PURPOSE Topical photodynamic therapy (PDT) is potentially useful for the treatment of non-melanoma skin cancer and other skin diseases. We investigated the therapeutic effects of PDT using topical application of aluminum phthalocyanine chloride (AlClPc) and a diode laser emitting at 670 nm in murine non-melanoma skin carcinomas. METHODS AlClPc solution (0.7% w/v) was applied to tumors in mice for 1-6 h. The penetration depth and the optimum drug-light interval were assessed using… CONTINUE READING
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