Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer

  title={Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer},
  author={K. W. Cheng and G. Mattheolabakis and C. Wong and N. Ouyang and Liqun Huang and P. Constantinides and B. Rigas},
  journal={International Journal of Oncology},
  pages={1199 - 1203}
Phospho-sulindac (P-S, OXT-328), a novel sulindac derivative, has shown superior anticancer efficacy and safety compared to sulindac. In this study, we investigated the efficacy of topical P-S hydrogel in the treatment of non-melanoma skin cancer in preclinical models. P-S is a potent inhibitor of A431 epidermoid carcinoma in vitro and achieves this effect by inhibiting cell proliferation and inducing apoptosis. The anticancer efficacy of topical and oral P-S was further evaluated in mice… Expand
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  • G. Xie, Y. Sun, +5 authors B. Rigas
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • 2011
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