Topical permeation characteristics of diclofenac sodium from NaCMC gels in comparison with conventional gel formulations.

@article{Mohammed2001TopicalPC,
  title={Topical permeation characteristics of diclofenac sodium from NaCMC gels in comparison with conventional gel formulations.},
  author={Fergany A Mohammed},
  journal={Drug development and industrial pharmacy},
  year={2001},
  volume={27 10},
  pages={
          1083-97
        }
}
Topical gel formulations of diclofenac sodium were prepared by using sodium carboxymethylcellulose (NaCMC), a low-toxicity cellulose polymer as a gel-forming material that is biocompatible and biodegradable. The influence of various formulation variables, such as initial drug concentrations and NaCMC concentration, and certain skin permeation enhancers on release characteristics of the diclofenac sodium from the prepared gels through a standard cellophane membrane was studied in comparison with… CONTINUE READING
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